
42 segments available
Robert Langer is a professor at MIT and one of the most cited researchers in history, specializing in biotechnology fields of drug delivery systems and tissue engineering. He has bridged theory and practice by being a key member and driving force in launching many successful biotech companies out of MIT. Support this podcast by signing up with these sponsors: - MasterClass: https://masterclass.com/lex - Cash App - use code "LexPodcast" and download: - Cash App (App Store): https://apple.co/2sPrUHe - Cash App (Google Play): https://bit.ly/2MlvP5w EPISODE LINKS: Bob's Lab Website: https://langerlab.mit.edu/ Bob's Google Scholar: https://scholar.google.com/citations?user=5HX--AYAAAAJ Bob's Wiki: https://en.wikipedia.org/wiki/Robert_S._Langer PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ Full episodes playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOdP_8GztsuKi9nrraNbKKp4 Clips playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOeciFP3CBCIEElOJeitOr41 OUTLINE: 0:00 - Introduction 3:07 - Magic and science 5:34 - Memorable rejection 8:35 - How to come up with big ideas in science 13:27 - How to make a new drug 22:38 - Drug delivery 28:22 - Tissue engineering 35:22 - Beautiful idea in bioengineering 38:16 - Patenting process 42:21 - What does it take to build a successful startup? 46:18 - Mentoring students 50:54 - Funding 58:08 - Cookies 59:41 - What are you most proud of? CONNECT: - Subscribe to this YouTube channel - Twitter: https://twitter.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Instagram: https://www.instagram.com/lexfridman - Medium: https://medium.com/@lexfridman - Support on Patreon: https://www.patreon.com/lexfridman
In this segment, Lex Fridman introduces Robert Langer, a prominent MIT professor and a leading figure in biotechnology. Langer is recognized for his groundbreaking work in drug delivery systems and tissue engineering, and he has played a pivotal role in launching successful biotech companies. The introduction sets the stage for a deep dive into Langer's contributions to medicine and science.
"the following is a conversation was Bob Langer professor at MIT and one of the most cited researchers in history specializing in biotechnology fields of drug delivery systems and tissue engineering he..."
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"quick summary of the ads to sponsors cash up a master class please consider supporting the podcast by downloading cash app and using code Lex podcast and signing up a masterclass comm slash Lex click ..."
Robert Langer shares his perspective on the connection between magic and science. He discusses how both can surprise us and evoke fascination, drawing parallels between the wonder of scientific discoveries and the allure of magic tricks. Langer reflects on the duality of understanding the mechanics behind magic while also appreciating the astonishment it brings.
"the middle that can break the flow of the conversation this show is presented by cash app the number one finance app in the App Store when you get it use collects podcast cash app lets you send money ..."
In this light-hearted segment, Langer describes one of his favorite magic tricks, 'the invisible pack.' He explains how the trick works and the joy it brings to both the magician and the audience. This anecdote serves to illustrate the theme of wonder that permeates both magic and scientific discovery.
"Langer you have a bit of a love for magic do you see a connection between magic and science I do I think magic can surprise you and you know and I think science can surprise you and there's something ..."
Langer opens up about his experiences with rejection in his early career, particularly regarding his groundbreaking research on blood vessel growth. He recounts the emotional impact of receiving rejection letters from prestigious journals and how these experiences shaped his resilience and determination in the field of science.
"the into the science as of today you have over two hundred ninety five thousand citation an h-index of 269 you're one of the most sighted people in history and the most cited engineer in history and y..."
Langer discusses the spontaneous nature of generating big ideas in science. He reflects on the influence of mentors and the importance of exposure to innovative thinking. This segment emphasizes the significance of recognizing potential in ideas that could lead to transformative advancements in biotechnology.
"advice to students to do something big do something that really can change the world rather than something incremental how did you yourself seek out such ideas is there a process is there a sort of a ..."
In this segment, Langer addresses the complexity of human biology and the challenges it presents for scientific research. He acknowledges the progress made in understanding biological systems while emphasizing that much remains to be discovered. This discussion highlights the intricate relationship between biology and the development of new medical technologies.
"drug delivery for example is the notion is the initial notion kind of a very general one that we should be able to do something like this yeah and then you start to ask the questions of well how would..."
Langer explains the significance of blood vessel research in the context of cancer treatment. He describes how understanding blood vessel growth can lead to breakthroughs in stopping tumor progression. This segment underscores the critical role of innovative research in addressing major health challenges.
"body is there a solid understanding across the populations of humans that are solid reliable knobs that can be controlled I think that's hard to do about on the other hand whenever we make a new drug ..."
In this segment, Langer recounts his early research on angiogenesis inhibitors during his postdoctoral work. He shares the challenges faced in isolating effective molecules to stop blood vessel growth and the significance of their findings in the field of cancer treatment. This narrative illustrates the trial-and-error nature of scientific discovery and the persistence required in research.
"shot what we wanted to see if we could find substances that could stop that from happening so first I mean there are many steps first we had to develop a bio essay to study blood vessel growth again t..."
Langer discusses the development of a bioassay to study blood vessel growth, which was essential for his research. He explains how this technique allowed for the quantification of blood vessel growth and the isolation of substances that could inhibit it. This segment highlights the innovative methodologies that paved the way for advancements in drug discovery.
"words there yeah that's the the first of all polymer molecules big big molecules so the water polymers what's bio sa the the what is the process is trying to isolate this whole thing simplified to whe..."
Langer reflects on the lengthy and costly process of bringing a new drug to market, using the example of Avastin, which was approved 28 years after his initial research. He emphasizes the collaborative efforts and advancements made by various companies in the biotech industry. This segment underscores the complexities and challenges of drug development in the pharmaceutical landscape.
"happen so that was sort of the what we call the bio sa is the way that we would study that so size of what is a by us which part is the bio sa all of it in other words the bio SAS is the way you study..."
In this segment, Langer explains the strategy of cutting off blood supply to tumors as a means to shrink them and enhance the effectiveness of other therapies. He discusses the rationale behind this approach and its implications for cancer treatment. This insight reveals the innovative thinking required in the fight against cancer.
"for all kinds of cancers and actually for many eye diseases to where you have abnormal blood vessel growth macula so in general one of the key ways you can alleviate so what's the hope in terms of tum..."
Langer shares his experiences of feeling 'in the dark' during his early research, highlighting the complexities of biology and the uncertainty inherent in drug discovery. He discusses the balance between systematic approaches and serendipitous discoveries in the field. This segment captures the challenges faced by researchers in understanding biological systems.
"small tumor than a big one is that an obvious idea I mean it seems like a very clever strategy in this war against yeah cancer well you know in retrospect it's an obvious idea but when dr. Folkman and..."
Langer outlines the multi-step process involved in drug discovery, from initial theories to clinical trials. He emphasizes the importance of safety and efficacy testing, as well as the various stages of development. This segment provides a comprehensive overview of the rigorous process that underpins the creation of new pharmaceuticals.
"human body is complicated right we'll establish this quantum mechanics and physics is a theory that works incredibly well but we don't really necessarily understand the underlying nature of it so our ..."
In this reflective segment, Langer marvels at the human capacity for innovation, particularly in the field of pharmaceuticals. He discusses the evolutionary journey that has led to our ability to create drugs that improve health. This philosophical perspective highlights the remarkable achievements of science and technology.
"serendipitous discovery and art or is there a systematic science to trying different chemical reactions and how they how they affect whatever you trying to do like shrink blood vessels yeah I don't th..."
Langer addresses the critical challenges in drug delivery, including targeting specific cells and overcoming biological barriers. He discusses the need for innovative delivery systems that can effectively transport drugs to their intended sites. This segment emphasizes the ongoing research and development efforts in the field of drug delivery.
"create drugs chemicals that are able to improve some aspects of our bodies Hey or is it quite natural that we were able to discover these kinds of things well at a high level it is amazing I mean evol..."
In this segment, Langer explores the concept of smart drug delivery systems that can respond to physiological signals in the body. He discusses the potential for intelligent microchips to enhance drug delivery and the future possibilities of nanotechnology in medicine. This insight reveals the cutting-edge advancements being made in drug delivery technology.
"I mean there are a lot I mean I'd say one is could you target the right cell like we talked about cancers or some way to deliver a drug just to the cancer cell and no other cell another challenge is t..."
Langer discusses the potential applications of artificial intelligence in drug development, particularly in analyzing chemical data and predicting successful drug candidates. He highlights the importance of data-driven approaches in enhancing the drug discovery process. This segment illustrates the intersection of technology and biotechnology in modern medicine.
"so that that's an example so from an AI robotics perspective how close are these drug delivery systems to something like a robot or they're totally wrong to think about them as intelligent agents and ..."
In this thought-provoking segment, Langer reflects on society's reliance on pharmaceutical drugs and the implications of this dependence. He raises questions about proper prescribing practices and the broader societal impact of drug use. This discussion invites listeners to consider the ethical dimensions of pharmaceutical innovation.
"but someday I expect we will be so some of it is just the shrinking of the technology that's a part of it that's one of the things in general what role do you see AI sort of there there's a lot of wor..."
Langer explores how artificial intelligence can enhance drug development processes. He explains the potential of AI to analyze chemical data from high-throughput screenings, identifying patterns that could lead to the discovery of new drugs for various diseases.
"chain I do I think that AI can be useful and a number of parts of the chain I mean one I think if you get a large amount of information you know say you have some chemical data because you've done hig..."
In this segment, Langer reflects on society's reliance on pharmaceutical drugs, discussing their impact on life expectancy and quality of life. He emphasizes the need for improved access to medications, especially in developing countries, and the ongoing challenge of creating better drugs for diseases.
"we talk about another exciting another exciting space which is tissue engineering what is tissue engineering or regenerative medicine you know so that tissue engineering regenerative medicine have to ..."
Robert Langer introduces the concept of tissue engineering and regenerative medicine, explaining the process of building organs or tissues from scratch. He discusses the potential for creating organs on chips to improve drug testing and reduce animal testing.
"course from stem cells is there are other methods what are the different possible flavors here yeah well I think I mean there's multiple components one is having generally some type of scaffold that's..."
Langer outlines the current advancements in tissue engineering, including the successful creation of skin and blood vessels. He highlights ongoing clinical trials aimed at helping patients with various medical conditions, showcasing the progress in this innovative field.
"body so is there a nervousness it's not a bad word says there possibility to weave into the scanner as a computational component so if we talk about electron ships some some ability to sense control s..."
In this segment, Langer discusses the challenges of tissue acceptance in the human body, particularly the issue of rejection. He explains various strategies being explored to improve acceptance rates, including encapsulation techniques and the use of the patient's own cells.
"groups have made them different companies and different professors but they've been approved for burn victims and for patients with diabetic skin ulcers that's amazing okay so skin what else well at d..."
Langer shares his optimistic vision for the future of organ regeneration, discussing the potential to regenerate various tissues and organs. He emphasizes the importance of ongoing research and the various strategies that could lead to breakthroughs in regenerative medicine.
"maybe in particular you might mean rejection by the body so there are multiple ways that people are trying to deal with that one way is which was what we've done and with Dan Anderson one of my former..."
Langer reflects on the implications of tissue engineering for human longevity. While he doesn't foresee radical increases in lifespan, he believes that advancements in this field will lead to improved quality of life and potentially longer lives for individuals.
"possibilities of tissue engineering is do you see some tissues more difficult than others what are the possibilities here yeah Wow of course I'm an optimist and I also feel a timeframe if we're talkin..."
Langer discusses the revolutionary CRISPR technology, highlighting its potential to edit genes and combat diseases. He acknowledges the complexity of the human body and the challenges that come with gene editing, while expressing optimism about its future applications.
"scientific idea in biology nearing that you've come across in your years of research I apologize for the romantic no that's an interesting question I certainly think what is happening right now with C..."
In this segment, Langer addresses the nature of progress in medicine and bioengineering. He explains that while there are significant breakthroughs, much of the advancement comes from incremental work, emphasizing the importance of both in the field.
"of ability to copy and paste I mean everything like we said the human body is complicated is that Mele difficult to do I think it is exceptionally difficult to do but that doesn't mean they won't be d..."
Langer elaborates on the financial aspects of drug development, detailing the high costs associated with clinical trials. He explains the rigorous process required to prove a drug's safety and efficacy, which constitutes the majority of the development expenses.
"too so in terms of stepwise that's the interesting notion do you see that if you look at medicine or bioengineering do you see that there is these big leaps that happen every decade or so or some dist..."
In this segment, Langer explains the steps involved in the patenting process, from initial research and discovery to filing a patent with the United States Patent and Trademark Office. He discusses the challenges of obtaining a patent, including the potential for multiple rejections and the importance of having strong claims to protect innovations in medicine.
"they have to be really carefully controlled studies and you know you'd have to manufacture the drug you'd have to you know really watch those patients you have to be very concerned if you know that th..."
Langer shares his insights on what it takes to build a successful biotech startup, emphasizing the importance of having strong business partners alongside scientific innovation. He outlines key factors for success, including having a solid discovery platform, effective patenting, and a passionate team dedicated to making a difference in healthcare.
"you've been part of launching 40 companies together worth again numbers could be outdated but an estimated twenty three billion dollars you've described your thoughts on a formula for startup success ..."
In this segment, Langer discusses the various criteria that influence decisions on which research projects to pursue in a startup. He highlights the importance of market size, availability of animal models, clarity of clinical trial endpoints, competition, and reimbursement considerations, illustrating the multifaceted nature of strategic planning in biotech.
"people's lives maybe you could mention the business component it's funny to hear great side to say that there's value to business folks oh yeah well that always said so what what value what business i..."
Langer reflects on his experience leading one of the largest academic labs in the world, emphasizing the importance of fostering a positive environment for researchers. He believes that when researchers feel they are working on impactful projects, they are more likely to be happy and productive, which ultimately benefits the lab's mission.
"whether you do what you do for a second third or fourth so you lead one of the largest academic labs in the world with over ten million dollars in annual grants and over 100 researchers probably over ..."
In this segment, Langer discusses how he inspires researchers to achieve their best work. He emphasizes the importance of communication, support, and sharing personal experiences of overcoming setbacks to motivate his team. Langer believes that fostering a sense of purpose and progress is key to maintaining enthusiasm in research.
"but through brainstorming and so on what's your role and how difficult it is as a group in this in this collaboration to arrive at these big questions that might have impact well the big questions com..."
Langer shares his thoughts on the evolving landscape of science, particularly the trend of researchers moving to industry. He discusses the importance of maintaining a balance between academia and industry, highlighting concerns about funding for basic research and the need for innovative teaching methods to enhance scientific education.
"and so forth but but yeah I think I try to do that as the one who leads the lab so you have this exceptionally successful lab and and one of the great institutions in the world MIT what and yet sort o..."
In this segment, Langer explores the challenges philanthropists face when deciding where to invest in scientific research. He emphasizes the importance of having a clear vision and understanding the specific needs of different research areas, using examples of notable philanthropists who have directed their funding based on personal experiences with health issues.
"you know it would be great if we as a society had come up with better ways to teach you know so that people all over could learn better you know so I think there were a number of things that would be ..."
In this segment, Langer emphasizes the importance of nurturing young talent in science. He discusses how funding decisions can impact emerging researchers and the need for a balance between supporting established labs and fostering new ideas from younger scientists.
"solving it sure well I think what I do for the first thing is different philanthropists have different visions and I think the first thing is to form a concrete vision of what you want some people I m..."
Langer addresses the limitations of the academic system that often categorizes researchers into specific disciplines. He advocates for a broader vision that embraces interdisciplinary approaches, citing examples of successful hires at MIT that reflect this progressive mindset.
"go seek out people or they can put a request for proposals and see who does the best you know I'd say both David Koch and Bill Gates did exactly that they sought out people most of them you know or wh..."
Langer expresses optimism about the future of cancer research, discussing the complexities involved in finding a cure. He believes that a combination of biology and engineering will be crucial in addressing this grand challenge, highlighting the collaborative nature of scientific progress.
"of the vision of the leadership who who do things like that do you think one day you mentioned David Koch and cancer do you think one day will cure cancer yeah I do I mean I coached one day I don't kn..."
On a lighter note, Langer shares his thoughts on the intersection of engineering and culinary arts, specifically in creating the perfect cookie. He discusses the potential role of AI and chemistry in food engineering, blending humor with insights into innovation.
"needs to be done well that's a beautiful vision for engineering so on a lighter topic I've read that you love chocolate and mention two places venom Bill's chocolate thorium and the chocolate cookies ..."
Reflecting on his career, Langer expresses pride in his students' achievements. He highlights their successes in various fields, including prestigious positions in academia and industry, and shares the fulfillment he derives from mentoring the next generation of scientists.
"than engineering I think there's some of both I think I think engineer will probably help someday and what about chocolate same thing same thing you have to go to see some of David Edwards stuff you k..."
In the closing moments, Langer shares a poignant quote from Bill Bryson about the privilege of existence. He reflects on the significance of life and the human capacity to appreciate and improve it, leaving listeners with a thoughtful perspective on their own lives.
"do so much good and be happy well I think that's the perfect way to end it Bob thank you so much for talking it was an honor good good questions thank you thanks for listening to this conversation wit..."