"hi and welcome to the a 16z podcast I'm Hannah and today we're talking about the science of life extension are we finally just around the corner from a treatment for getting old in this episode we tal..."

"dr. Thomas Rando from Stanford who directs the Glenn Center for the biology of Aging then a 16-0 partner Vijay Pandey joined by Kristin Fortney CEO of bio age so let's start off with a simple question..."

"distinction because so much experimentation goes into lifespan extension in animals but really the translation is making people healthier longer yes they may live a little longer but what we really wa..."

"in the field of aging across say the decades there's a pivot happening now that I think is really remarkable it's it's changed a lot in the last two decades and then every five years you see another b..."

"exciting about the state of the field right now the field has focused in academia on invertebrate models because they're sort of more attractable they have shorter life spans but because of sort of ne..."

"treatment we have would be from the pop culture perspective like caloric restriction this idea of old blood and new blood some of the actual science has roots in old ideas and some of it is based in c..."

"fertile for extending the health span of a life yeah there's a few different things that have shown promise in a million systems so there's a pair of iosys as Tom discusses his which is his expertise ..."

"it speaks um one question I have which is what would this look like would this look like a small molecule that actually would if you take it every day as some sort of supplement would would it help yo..."

"turned into a pill mm-hmm the plasma coming from the para bios's worked that idea of plasma infusions you know actually can be done but it's much more invasive you have to inject plasma to people we r..."

"of benefit I can imagine a science-fiction story right now because you can develop an antigen for that antibody and now you have a vaccine for aging you know the role of data because not just right ab..."

"for the first time did they accelerate it I mean are we still in a position where we have to actually watch people age you know decades to know whether that first there is a way around that so you can..."

"excited about that and the second answer to that question is that I think that aside from accelerating research into human aging it's also accelerating research into mammalian aging in general because..."

"system for you know evaluated many more drugs than thirty so I think there's a lot of low-hanging fruit there what is intriguing about the ability to get this information from blood whether we're talk..."

"excellent point like you know biotech companies drug discovery companies have a lot of challenges to face and I think there's even more in the case of an aging company because even if we do discover a..."

"the notion is maybe everyone will live longer if they take the med foreman so especially in people who have diabetes but also in people who do what epidemiologic data is that so there's no epidemiolog..."

"really it's it's the notion is that it's preventing the notion is that that agent whether the concept that's out there's aging is the major risk factor for all of these nieces heart disease cancer Alz..."

"delay the onset of all these stabilities so that's at the root cause right all of these approaches are getting at the root cause not all the symptoms and diseases that are associated that so how does ..."

"be approved for treatment of healthy people and is that because of the time because it takes so long or is it no it's just just the historical context and i remember so probably 15 years ago i was tal..."

"shift a little bit well even this tame trial being discussed and being presented to the FDA and the FDA discussing it is already a major step forward I mean that that would not have happened 10 years ..."

"prevention slowing drug test it in these conditions if it works then you may be on to something so can you pick multiple ones and are there certain ones that are that tend to crop up over and over aga..."

"early onset Alzheimer's disease so it's in trial and we don't you know don't know if it'll work yet but but so in theory in a short time plasma infusions for certain diseases might be as might be a tr..."

"to be thought in a different way and that it's you know more akin to like seatbelts and airbags but but there is also a cost I mean say we did all add 40 years to our lives you know which would be ama..."

"and we think about our very humanity in these terms and what does it mean when you when we when we open that and how we think about humanity . we're still not talking about infinity there's a big diff..."