"the drugs that we have are not fully utilized to treat every disease that they possibly can and it's our mission to take all that incredible work and just do the little bit of more effort it takes to ..."

"well hello everyone it's Jim o shasy with yet another infinite Loops today I have a very special guest a member of my family well kind of a member of my family uh Dr Grant Mitchell who man Grant you h..."

"much for that kind introduction Jim and uh the the uh problem is dire more dire than you even uh portrayed there it's actually around depending on the definition of disease you choose 22,000 diseases ..."

"that we've launched called every cure is designed to overcome those barriers and and pursue that research and make sure that patients get these treatments I recall a lunch many years ago that you and ..."

"feel like I'm G to die I said said what how what are you talking about David you're the healthiest guy I know um and just a few short weeks later he was in the ICU uh and nearly in a coma his his orga..."

"the uh it kills you and so he was given probably three years to live and we being naive early 20 year olds um 20-some year olds we looked at this problem and said well if no one else is working on thi..."

"study David's blood and try and identify patterns in the way that the sakin were expressing themselves and to see if maybe we could figure out which pathway was actually going wrong in his body and th..."

"of what we were doing was you know trying to understand the underlying mechanisms of these disease and then finding drugs that already exist that line with those mechanisms so we don't have to spend a..."

"databases to identify subpopulations where a drug might perform better might be higher in efficacy or or better in safety and and we realized that that's really in a way it's kind of drug repurposing ..."

"know like I said before more data structured better you have models like these large language models that that are able to digest all of medical literature output it in a structured fashion compile it..."

"and then there'd be a massive attack and and it wasn't like clockwork uh like your colleagues uh but um when when she died in 1971 it was like nobody knew very much at all about the about the disease ..."

"something like that out and to be able to do it uh to have the opportunity to do it more and at scale and and have the opportunity to save potentially millions of lives is uh is a huge motivation for ..."

"an AI company because if you're if you're want to build the world's best AI platform for drug repurposing you're going to need the world's best data set to train it and you're not going to get your ha..."

"knowledge we have as Humanity every drug every Target every protein every Gene every pathway cell type organ system Etc and how they relate to different phenotypes symptoms and and diseases and so eve..."

"people have constructed uh the actually NIH funded a a program called the inats translator program where a number of these knowledge grafts have been constructed other groups are doing it a lot of pri..."

"protection well how's that data going to fit into my knowledge graph well you can imagine that I now if I have the the data set that they're working with I know that there's a mutation that results in..."

"considered before by experts before so to answer your question again is you know we're not doing that work ourselves but we integrate the knowledge from that work so it can train our models and so we ..."

"value with and it's not their fault that there's just no incentive to pursue additional research around drugs that are off patent and are generic and no one can make money on and so that actually repr..."

"takes to find the additional diseases that that they could potentially treat uh so I I am uh more than happy to to work with the pharmaceutical industry and they're generally happy to to work with us ..."

"of it if if we do if we do the research um and we're not looking to pursue IP we're not looking to capture IP and we're not looking to then license it out or or uh or sell it to someone else uh we're ..."

"potential outcomes from you building these amazing graphs and data sets be where you could find a not only a new use for an existing drug that's been approved for something else but a combination of e..."

"have to if you if you develop a novel compound you have to go all the way through the entire clinical development of an approval process indd phase one phase two phase three trials um this takes years..."

"through clinical trials and through regulatory approvals into patients so here you are an AI company you've hired up your team of you know 50 data scientists and experts and you come up with your hypo..."

"repurposing solves that tension it allows us to go from hypothesis to validation in a much tighter feedback loop so what we're doing is something that both helps patients in the fastest and cheapest w..."

"whereas of course AI uh that is kind of what it's designed to do have you have you looked at um I I presume but correct me if I'm wrong uh are you extending it to not just existing drugs uh in the mar..."

"application in artificial intelligence is that you know you can't trust the AI completely we're certainly not there you know I think someday in the future maybe a hundred years from now we'll say my G..."

"a tricky thing to do is you know disease uh drug a for disease X compared to drug B for disease Y how do you compare the possibilities of each of those 0 to one so we create that normalized score and ..."

"that you need a a really smart uh you know head of translational translational science to make that last sort of decision that what's going to go into patients and and how how it's all going to work y..."

"requires us to create the perfect Knowledge Graph the knowledge graph that is is effectively the exact representation of of reality of of of the human body and and we're just not there yet there's so ..."

"I'm I'm interested in for example have you considered like using uh medical chat Bots with existing patients where they could take uh an interrogation or a conversation Andor uh do a metaanalysis of a..."

"effectively every single paper and extract all those biomedical Concepts that I described before so if it ever mentions you know a protein or or a drug or a disease Etc not just extracting the the con..."

"and it's not just chatbots I think that uh another use case that we've explored that we think might be advantageous and helpful would be when we were discussing various use cases in the medical stack ..."

"mean like the knowledge explosion that we are are undergoing right now and the Innovations and and whatnot certainly I you know I'm 63 and this is the the most I've ever seen in my lifetime have you e..."

"going forward and for people that are out there trying to figure out you know what they want to do in life uh you know you don't necessarily have to be a Cod but if you can speak the language and then..."

"backers are uh some some really great philanthropies uh Chan Zuckerberg initiative laa Hill uh Arnold Ventures um the Carolyn Smith Foundation uh uh Newar at uh at Flagship pioneering the founder of m..."

"you know can be an extremely expensive Endeavor so uh every every dollar counts we're an extremely Frugal organization we we rely on free office space and and uh and and as much support as we can get ..."

"what was the biggest surprise as you uh did the research um what what uh What uh emerged as a solution to a disease that had you kind of as a doctor and your colleagues scratching your heads and think..."

"what motivates all of us in the meantime you know we we actually use the graph and and the preliminary results to inform some of our thinking and and we've been able to help a a small amount of patien..."

"every drug is unlocked to treat every disease that it possibly can yeah and and that brings in the uh idea of using this as open- Source AI which I I think uh I'm a huge fan of because of everything y..."