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Taking Bold Bets: NIH and the Future of Biomedical Science

Taking Bold Bets: NIH and the Future of Biomedical Science

16 segments available

Dr. Jay Bhattacharya is one of the country’s top medical experts and a 24-year professor of medicine at Stanford. After being censored and deplatformed during COVID for his role in opposing harsh lockdowns, he was appointed Director of the National Institutes of Health by President Trump in 2025. a16z General Partners Erik Torenberg, Vineeta Agarwala, and Jorge Conde join Dr. Bhattacharya to discuss the administration’s role in tackling the autism crisis, how to restore public trust in health authorities, how to make the NIH more dynamic and efficient, and how to streamline publishing and restore academic freedom. Timecodes: 00:00 Introduction 00:59 Autism Research Initiatives Announced 02:01 New Findings: Leucovorin and Tylenol in Pregnancy 04:40 Addressing Preterm Birth & Broader Health Concerns 06:10 The Replication Crisis in Science 09:26 NIH Funding, Grant Review, and the Silicon Valley Spirit 12:47 Grant and Review Process 14:26 Portfolio Management & Allocation at NIH 26:23 The Challenge of Supporting Early Career Investigators 31:23 Allocating Grants and Training Under the New Administration 35:46 Academic Freedom and Scientific Publishing 38:34 Rebuilding Public Trust in Science & Public Health 41:57 Communicating Uncertainty & Scientific Honesty 48:58 NIH Priorities: Nutrition, Chronic Disease, and AI 54:15 Advice for the Next Generation of Scientists 56:37 The Role and Limits of AI in Science Resources: Find Dr. Bhattacharya on X: https://x.com/DrJBhattacharya and https://x.com/NIHDirector_Jay Find Erik on X: https://x.com/eriktorenberg Find Jorge on X: https://x.com/JorgeCondeBio Find Vineeta on X: https://x.com/vintweeta Learn more about the NIH: https://www.nih.gov/ Stay Updated: If you enjoyed this episode, be sure to like, subscribe, and share with your friends! Find a16z on X: https://x.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711 Follow our host: https://x.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Segments Timeline

1
0:00 - 1:01
1:00 duration222 words

Introduction

"The American people are not stupid. In fact, they're quite smart. And when we talk to them in ways where we show respect for their intelligence with data, allow people to disagree, but then have the e..."

2
1:01 - 2:02
1:01 duration219 words

Autism Research Initiatives Announced

"months ago when I first started this job, uh Secretary Kennedy challenged me to help get answers for families with autistic kids. I mean was there's uh the prevalence has been rising for decades. Like..."

3
2:02 - 4:41
2:38 duration546 words

New Findings: Leucovorin and Tylenol in Pregnancy

"it's folinic acid. It's called but it's like it serves almost like a a way to deliver folate to the brain. um where for when some when some kids have folate processing defic folate is you know somethi..."

4
4:41 - 6:11
1:30 duration312 words

Addressing Preterm Birth & Broader Health Concerns

"initiative there to again, you know, um launch not only fascinating science projects hopefully, but also science projects which lead to clinical um insight into why that's happening to moms across Ame..."

5
6:11 - 9:26
3:15 duration668 words

The Replication Crisis in Science

"to higher standards. We have to be when we when we talk about people about science has to be rigorous and reproducible. Something I've been focused on um really sharply as my time as NI instructor is ..."

6
9:26 - 12:49
3:22 duration727 words

NIH Funding, Grant Review, and the Silicon Valley Spirit

"just in terms of maybe we could zoom out. You mentioned you you you know took over six months ago. What are so your reflections so far in terms of your your activity and achievements to date and and a..."

7
12:49 - 14:26
1:36 duration354 words

Grant and Review Process

"that the mechanism for reviewing the grants say at the NIH became overly cautious or did the scientists themselves become overly cautious? Well, I mean those are closely linked. It's a peerreview orga..."

8
14:26 - 26:24
11:58 duration2275 words

Portfolio Management & Allocation at NIH

"Yeah. It's interesting. It's sort of why many great venture partnerships um you know ourselves included are not consensus driven. You can't drive, you can't require unanimous consent to fund a big bol..."

9
26:24 - 31:23
4:58 duration1029 words

The Challenge of Supporting Early Career Investigators

"execution to use Venita's phrasing on selecting for the the innovation that if you will bubbles up from the bottom. And it's a hard question actually. It's something that's the top of my mind. Um and ..."

10
31:23 - 35:46
4:22 duration846 words

Allocating Grants and Training Under the New Administration

"I love to hear the interest in advancing early career investigators, but we can't have that conversation without talking about the universities from where they tend to come. And so, you know, I was a ..."

11
35:46 - 38:35
2:49 duration532 words

Academic Freedom and Scientific Publishing

"Last week you announced um some really interesting initiatives around academic freedom and many folks know your voice kind of reached the national stage in part because of your ardent um desire to see..."

12
38:35 - 41:57
3:21 duration710 words

Rebuilding Public Trust in Science & Public Health

"better uh outcomes better health one of the big avenues that of course this country uses and it's really had as a gold standard in the past is um you know having this extraordinary public health infra..."

13
41:57 - 48:58
7:01 duration1415 words

Communicating Uncertainty & Scientific Honesty

"thoughts on you know how do you convey uh you know uh recommendations and guidance in the face of uncertainty and incomplete information right to because going back to your point like in an ideal worl..."

14
48:58 - 54:17
5:18 duration1039 words

NIH Priorities: Nutrition, Chronic Disease, and AI

"You mentioned that the the three priorities of n you have are nutrition, chronic disease and integrating AI. Maybe can you uh flesh out a little bit on on the last two where what you see as most promi..."

15
54:17 - 56:38
2:21 duration471 words

Advice for the Next Generation of Scientists

"last question, if you had one message for the rising star scientist contemplating a career in science where they can bring the best of their abilities to making science better, smarter, faster. you kn..."

16
56:38 - 58:59
2:21 duration419 words

The Role and Limits of AI in Science

"looking to the future um if we if we end where we started where you know uh you talked about the NIH's highest ambition is to improve the health of the American people whether that's measured in life ..."

Taking Bold Bets: NIH and the Future of Biomedical Science — Dr. Jay Bhattacharya | Searchlore