"the following is a conversation with david sinclair he is a professor in the department of genetics at harvard and co-director of the paul f glenn center for the biology of aging at harvard medical sc..."

"does meaning require death or does it merely require struggle reprogramming our biology will require us to delve deeper into understanding the human mind and the robot mind both of these efforts are a..."

"there's uh there's something i really appreciated in opening your book you talked about your grandmother and on this kind of theme on this kind of topic uh she first of all had a big influence on you ..."

"and show to whoever's watching us whether it's aliens or some future human historian that we can do better than we did in the 20th century you know we mentioned offline this idea of bringing people ba..."

"companies there's replica which is a chat engine that was born out of the idea of bringing the the founder uh lost her friend uh to uh he he got ran over by a car and the initial reason she founded th..."

"because there are people that i'd like to meet and i think it's easier than building a time machine one person i'd love to meet is benjamin franklin really well i wouldn't go back in time um i would b..."

"the best parts of the person maybe throw away the ugly parts and celebrate them even after they're gone so that's a really interesting opportunity you um you've also mentioned to me offline that you'r..."

"measuring me at a thousand times a second is my vibrations as i speak my orientation it can already has told me this morning how i slept where i slept what side i slept on uh we've got sneezing coughi..."

"inside tracker because i saw that there's some really cool things in there like it actually so maybe you can talk about i guess that you're collecting blood and to give it the data so and it has like ..."

"it's like a company consumer facebook company it is yes uh and i also want to democratize the ability to to just take a mouth swab eventually we don't need to have a blood test necessarily but for now..."

"if you eat that what works if you take that supplement what works and i was a co-author on a paper that showed that the recommendations for food and supplements um was better than the leading drug for..."

"uh and so so these programs will know us way better than we do and and our doctors as well the idea of going to a doctor once a year for an annual checkup and having you know males get a finger up the..."

"so i'm not against the profession at all yeah but i think that they need just as much help as anyone else does we wouldn't drive a car without a dashboard we wouldn't think of it so why would doctors ..."

"our bodies these arms if any of us even the strongest person in the world went in a cage with a chimpanzee the chimp could knock that person's head off no question so we're pathetic so we need to engi..."

"chase as to where what is the upstream defining factor if we boil it down what do we get so most biologists would say you can't boil it down it's too complex i would say you can boil it down to an equ..."

"the dysregulation of information in the cell and then so fast forward to now i've been looking in humans and mice because they live shorter and cheaper to study where the loss of information in our bo..."

"is there more concrete ways you think about the kind of information we want to preserve and also is there good ideas about regulators of that information about ways to prevent the distortion and degra..."

"the dna is wrapped up or looped out for the cell to access it and read it so it's similar to an excuse this analogy but it's a good one um a compact disc or a dvd those pits in the foil are the digita..."

"inspired largely by claude shannon's work at mit as well in the 1940s his theory mathematical theory of communication is just brilliant and so i've been looking for what he called the observer which i..."

"is there um the scratches do those come from are those programmed or are they failures meaning is it so if it's by design then there's like a encoded timeline schedule that the body's just on purpose ..."

"definitively the first one is broken chromosomes when a chromosome breaks the cell has to panic because that's either going to cause a cancer or kill the cell there's only two outcomes it's pretty muc..."

"that what can you give me hints uh whose fault is it and the ball's not coming back is it the proteins themselves like are they are they starting again i've been obsessed with the protein folding prob..."

"that's constantly changing we have in our bodies close to a trillion dna breaks every day and imagine that over 80 years what damage that does to our epigenomic information now we know that this is we..."

"but it's definitely old it's got all of the hallmarks of aging it's got diseases it looks old its skin is old it's got gray hair but importantly we can now measure age by looking at the scratches we c..."

"well and we can take a blind mouse that's lost its vision due to aging neurons aren't working well towards the brain reset those neurons back to a younger age and now the mice can see again these thre..."

"so i'm so optimistic that we're going into human studies in less than two years from now is there a place where ai can help sorry to inject one of the things i'm very excited about i'm passionate abou..."

"using it to generate these biological clocks to be able to read those scratches we're using it to predict the folding of proteins so we can target molecules and modulate their activity we're using it ..."

"week it'll eventually be terabytes per day and then we just go from there and i actually have trouble recruiting enough bioinformaticians a lot of our work is now just number crunching a part of that ..."

"are right in the middle we're living through what's going to be seen as one of the biggest revolutions in human health through the gathering of data about our bodies and 20 years ago people didn't wan..."

"to not collect the data because you're making if there's something really wrong with me and you're making decisions based on very few tests that's almost negligent when you have the opportunity to col..."

"and if i have data with me then i have like several orders of magnitude more knowledge and i think there's an aspect to where the doctor has to put their expert hat like take it off and actually be a ..."

"yeah so when the public wakes up to this they'll almost demand it like this this should be this should be accepted everywhere this is obvious it's gonna save a lot of money it's gonna improve the qual..."

"and then maybe policy creates rules to where you can share data you could delete the data and i think if i have the option to delete all my data that that a particular company has then i'll share my d..."

"in the capitalist system encourage the companies that are doing great work with that data well yeah health care data security is is number one on on my mind uh inside tracker made sure that that was t..."

"lifestyle side i've recently did a 72 hour fast it's just an opportunity to take a pause and be you know appreciate life think about like there's something about fasting that um encourages you to refl..."

"also the uglier things of jealousy and greed and hate and all those kinds of things you start to think okay how how do i manage this body to create a rich experience all that comes from fasting for me..."

"is that these longevity genes we work on we showed back in the early 2000s are turned on by fasting and at least in yeast we were the first to show that how calorie restriction fasting works to extend..."

"thing uh where i'm not good at is going beyond one day but have you ever fasted longer than uh than them 24 hours i tried doing two days i might have made it to the third and given up i'm i just find ..."

"give it at least two weeks because you there's a habit as well having something in your mouth chewing feeling that fullness you can break that habit and within two three weeks you'll have done it abso..."

"like 15 pounds something like that since i moved to austin texas and i i still keep the same diet but i eat a lot of meat in that one just because it's delicious because it's also the the the amazing ..."

"him he's like fuck it every once in a while you got to enjoy it and and then also coupled with that for him uh is just exercise like then faces demons the next day and just like burn a huge amount of ..."

"well sure i mean the first thing that's important to know is that while many people are interested slash obsessed with what they eat the data that's come out of animal studies at least is it's far mor..."

"now i wonder what are the costs down the line well think about what i i was saying about the trade-offs between growth and reproduction which is what a mouse does and a whale that grows slowly reprodu..."

"almost i'm asking uh almost like a anecdotal question unless you know the science uh well the science is still being worked out but from the synthesis of everything i've read i try to eat a diet that'..."

"that because it's terrible name and i take full responsibility with my friend conrad howitz the xeno means cross species and hormesis is the term that what doesn't kill you makes you live longer and a..."

"benefits that's the idea and we've evolved to do so this isn't a coincidence it's my theory our theory that we want to know when our food supplies is under adversity because we need to get ready for a..."

"as the vegetables that's the xenochromatic molecules i love that tone i'm gonna take that one with me thank you yeah oh i follow him on instagram is always screaming so you want the that he's basicall..."

"not very sweet so i would just say you're relatively low like you try to avoid sugary things as well yeah i'm fairly militant about that um i rarely would add sugar to anything occasionally i would um..."

"cyclists it was something like people that cycle over 80 miles a week have a 40 reduction in a variety of diseases certainly heart disease so that that's not even a question but what's interesting is ..."

"it's a percent or so a year and i don't want to be frail when i'm older and fall over and break my hip which is which happens every 20 seconds in this country so maintaining that strength but also doi..."

"this is maybe like five years ago i started listening brown noise when i work and uh the first time i listened to it something happened to my mind where it just went like zoomed in to like in a way th..."

"constantly looking for it's almost like um an encouraging and motivating of event that maybe there's other stuff out there maybe there's other brown noise like things out there that truly like almost ..."

"yeah though you have a different mind you have quite a beautiful mind so i suspect brown noise helps you focus and because you're probably all over the place if you don't control it yeah exactly i mea..."

"think about it this way but when you talk about the biological machine it's always these mechanisms that don't are not necessarily directly connected to the brain or the operation of the brain like wh..."

"where i almost never get stressed never there's nothing that i've never gotten angry in my lab i've got 20 kids sometimes it's like a most of the time it's like a kindergarten um i haven't lost my tem..."

"you know a week later you have either a doctor's report or a health recommendation and what can you get off a cheek swab well you can get anything you can get hormones stress levels stress hormones bl..."

"but when you go to the doctor first of all your doctor doesn't does treat you as though you're an average person and none of us are average there's no such thing but second of all we never know how we..."

"it's not a big deal so what's the maximum well we know that one human made it to 122 and a number of them make it into their teens i think that's also the next level of of uh of where we can get to wi..."

"to achieve of a prolonged sort of increased longevity is to replace the parts that break easily and keep because actually from your theory of um aging as a degradation of information it's an informati..."

"that are not functioning such as the the retina and other parts the visual cortex back here that that's going to be doable in terms of longevity maybe we could put something on the hypothalamus and st..."

"okay so we talked about biology let's forgive me but let's talk about philosophy for just a brief moment so somebody i've enjoyed reading ernest becker wrote the denial of death there's also martin he..."

"human and it because you know think about tribes that obsessed with longevity every day and that were going to die they probably didn't make much technological progress because they were just crying i..."

"that much sweeter is there something to that i think it's individual in my case it's completely wrong i appreciate you saying that i don't get joy out of every day because i think i'm going to die yea..."

"the universe yeah we're able to deeply appreciate the leaf or the cube and deeply appreciate ourselves which is uh it can be a curse but it's mostly a gift especially when you're such a beautiful poem..."