"the following is a conversation with manolas kellis his third time on the podcast he is a professor at mit and head of the mit computational biology group this time we went deep on the science biology..."

"is trying to understand the molecular basis of human disease what are some of the biggest challenges in your view don't get me started i mean irregularities standing human disease is the most complex ..."

"to zoom back out we've been talking about the genetic origins of diseases but i think it's fascinating to talk about what are the most important diseases to understand and especially as it connects to..."

"so each one of these problems have a genetic component and an environment component and so like when there's a genetic component what can we do about some of these diseases what what have you worked o..."

"interesting so yeah okay so that's what we're looking at then what have we been able to find in terms of which disease could be helped again don't get me started this is um we have found so much our u..."

"question but you know there's in physics there's a theory of everything do you think it's possible to move towards an almost theory of everything of disease from a genetic perspective so if this unifi..."

"how do you from the scientific perspective go from knowing nothing about the disease to going you said uh to go into the entire pipeline and actually have a drug or or a treatment that cures that dise..."

"you know crispr right crispr is this genome guidance and cutting mechanism it's what george like likes to call genome vandalism so you basically are able to one you can basically take a guide rna that..."

"mitochondria are little organelles they arose they only are found in eukaryotes u means good karyo means nucleus so truly like a true nucleus so eukaryotes have a nucleus prokaryotes are before the nu..."

"technologies the tools that came along that made this possible like what what are you excited about maybe if we just look at the buffet of things that you've kind of mentioned is there is this what's ..."

"simultaneously working on a paper on schizophrenia right now that is basically using the single cell profiling technologies using this editing and manipulation technologies to basically show how the m..."

"used to think of them as oh yeah they're microglia but in fact now we're realizing just even in that sort of least abundant of cell types there's this incredible diversity there the differences betwee..."

"biomarkers for this sort of early intervention in alzheimer's the other aspect that we're looking at is mosaicism we talked about the common variants and the rare variants but in addition to those rar..."

"other the somatic variants are pointing to neuronal energetics and oligodendrocyte functions that are not visible in the genetic lesions that you find for the common variants probably because they hav..."

"but there's you know there's just such a such a dramatic uh set of frontiers when it comes to aging research that you know will so what i often like to say is that if you want to re to to engineer a c..."

"so basically i see this confluence in my lab and many other labs of ai of you know sort of you know the next frontier of ai for drug design so basically these sort of graph neural networks on specific..."

"these different molecular pathways the delivery of specific drugs and specific interventions into specific cell types and again you've talked with bob langer about this there's you know many giants in..."

"through this combination of intervention so that that's in my view the field where basically computer science comes together with you know artificial intelligence statistics all of these other tools m..."