Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors: - SEMrush: https://www.semrush.com/partner/lex/ to get a free month of Guru - Pessimists Archive: https://pessimists.co/ - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get $200 off - BetterHelp: https://betterhelp.com/lex to get 10% off EPISODE LINKS: Manolis Website: http://web.mit.edu/manoli/ Manolis Twitter: https://twitter.com/manoliskellis Manolis YouTube: https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA Manolis Wikipedia: https://en.wikipedia.org/wiki/Manolis_Kellis PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ Full episodes playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOdP_8GztsuKi9nrraNbKKp4 Clips playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOeciFP3CBCIEElOJeitOr41 OUTLINE: 0:00 - Introduction 2:49 - Molecular basis for human disease 26:48 - Deadliest diseases 32:31 - Genetic component of diseases 41:22 - Genetic understanding of disease 57:09 - Unified theory of human disease 1:03:10 - Genome circuitry 1:28:13 - CRISPR 1:39:50 - Mitochondria 1:47:54 - Future of biology research 2:17:30 - The genetic circuitry of disease CONNECT: - Subscribe to this YouTube channel - Twitter: https://twitter.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Instagram: https://www.instagram.com/lexfridman - Medium: https://medium.com/@lexfridman - Support on Patreon: https://www.patreon.com/lexfridman
Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors: - Eight Sleep: https://www.eightsleep.com/lex to get special savings - NetSuite: http://netsuite.com/lex to get free product tour - ExpressVPN: https://expressvpn.com/lexpod to get 3 months free - InsideTracker: https://insidetracker.com/lex to get 20% off EPISODE LINKS: Manolis Website: http://web.mit.edu/manoli/ Manolis Twitter: https://twitter.com/manoliskellis Manolis YouTube: https://youtube.com/@ManolisKellis1 PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ Full episodes playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOdP_8GztsuKi9nrraNbKKp4 Clips playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOeciFP3CBCIEElOJeitOr41 OUTLINE: 0:00 - Introduction 1:28 - Humans vs AI 10:34 - Evolution 32:18 - Nature vs Nurture 44:47 - AI alignment 51:11 - Impact of AI on the job market 1:02:50 - Human gatherings 1:07:51 - Human-AI relationships 1:17:55 - Being replaced by AI 1:30:21 - Fear of death 1:42:17 - Consciousness 1:49:42 - AI rights and regulations 1:55:25 - Halting AI development 2:08:36 - Education 2:14:00 - Biology research 2:21:20 - Meaning of life 2:23:53 - Loneliness SOCIAL: - Twitter: https://twitter.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - Medium: https://medium.com/@lexfridman - Reddit: https://reddit.com/r/lexfridman - Support on Patreon: https://www.patreon.com/lexfridman
Manolis Kellis is a professor at MIT and head of the MIT Computational Biology Group. He is interested in understanding the human genome from a computational, evolutionary, biological, and other cross-disciplinary perspectives. Support this podcast by supporting our sponsors: - MasterClass: https://masterclass.com/lex - Eight Sleep: https://eightsleep.com/lex - Blinkist: https://blinkist.com/lex EPISODE LINKS: Manolis Website: http://web.mit.edu/manoli/ Manolis Twitter: https://twitter.com/manoliskellis Manolis Wikipedia: https://en.wikipedia.org/wiki/Manolis_Kellis PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ Full episodes playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOdP_8GztsuKi9nrraNbKKp4 Clips playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOeciFP3CBCIEElOJeitOr41 OUTLINE: 0:00 - Introduction 3:54 - Human genome 17:47 - Sources of knowledge 29:15 - Free will 33:26 - Simulation 35:17 - Biological and computing 50:10 - Genome-wide evolutionary signatures 56:54 - Evolution of COVID-19 1:02:59 - Are viruses intelligent? 1:12:08 - Humans vs viruses 1:19:39 - Engineered pandemics 1:23:23 - Immune system 1:33:22 - Placebo effect 1:35:39 - Human genome source code 1:44:40 - Mutation 1:51:46 - Deep learning 1:58:08 - Neuralink 2:07:07 - Language 2:15:19 - Meaning of life CONNECT: - Subscribe to this YouTube channel - Twitter: https://twitter.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Instagram: https://www.instagram.com/lexfridman - Medium: https://medium.com/@lexfridman - Support on Patreon: https://www.patreon.com/lexfridman
Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors: - Grammarly: https://grammarly.com/lex to get 20% off premium - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - Cash App: https://cash.app/ and use code LexPodcast to get $10 EPISODE LINKS: Manolis Website: http://web.mit.edu/manoli/ Manolis Twitter: https://twitter.com/manoliskellis Manolis YouTube: https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ Full episodes playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOdP_8GztsuKi9nrraNbKKp4 Clips playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOeciFP3CBCIEElOJeitOr41 OUTLINE: 0:00 - Introduction 2:18 - Music and life 41:51 - The number 42 47:52 - The question about the meaning of life 50:32 - Are humans unique in the universe? 56:16 - Human civilization 1:08:22 - Mars 1:10:15 - Human mind and the abstraction layers of reality 1:21:08 - Neural networks and intelligence 1:28:25 - Ideas as organisms 1:37:49 - Language 1:49:04 - Legacy 2:03:55 - Poems SONGS MENTIONED: [1] Dwros Gewrgiadis - An imoun plousios - https://www.youtube.com/watch?v=7akZoEQv6jI [2] Grigoris Bithikotsis - Ftoxologia - https://www.youtube.com/watch?v=TyGR24O0KQ8 [3] Sto perigiali to kryfo - https://www.youtube.com/watch?v=B-GBPx_GXQw [4] Michael Jackson - Man in the Mirror - https://www.youtube.com/watch?v=Zqe5NP86OCc [5] George Michael - Careless Whisper - https://www.youtube.com/watch?v=izGwDsrQ1eQ [6] Gainsbourg with Isabelle Adjani - Pull Marine - https://www.youtube.com/watch?v=o7MwHGHWgLk [7] Georges Moustaki - Le meteque - https://www.youtube.com/watch?v=MV8fGf-N06A [8] Jacques Brel - Ne me quitte pas - https://www.youtube.com/watch?v=q_bq5mStroM [9] Sting - Englishman In New York - https://www.youtube.com/watch?v=d27gTrPPAyk [10] Sting - Fragile - https://www.youtube.com/watch?v=lB6a-iD6ZOY [11] Pink Floyd - The Wall (When the Tigers Broke Free) - https://www.youtube.com/watch?v=E_5DRKZI1Ow [12] Pink Floyd - The Wall (One Of My Turns) - https://www.youtube.com/watch?v=BOay-7aqLks [13] Sting - Russians - https://www.youtube.com/watch?v=wHylQRVN2Qs [14] Joni Mitchell - Both sides now - https://www.youtube.com/watch?v=aCnf46boC3I [15] Leonard Cohen - I'm Your Man - https://www.youtube.com/watch?v=yOnXe8ttmjY [16] Alison Krauss & Union Station - The Lucky One - https://www.youtube.com/watch?v=jcRZ_J_VgNc CONNECT: - Subscribe to this YouTube channel - Twitter: https://twitter.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Instagram: https://www.instagram.com/lexfridman - Medium: https://medium.com/@lexfridman - Support on Patreon: https://www.patreon.com/lexfridman
Manolis Kellis is a professor at MIT and head of the MIT Computational Biology Group. Please check out our sponsors to get a discount and to support this podcast: - Public Goods: https://publicgoods.com/lex and use code LEX - Magic Spoon: https://magicspoon.com/lex link & using code LEX at checkout - ExpressVPN: https://www.expressvpn.com/lexpod Lex Fridman Podcast survey mentioned in the intro: https://www.surveygizmo.com/s3/5833660/Lex-Fridman-Podcast-Survey EPISODE LINKS: Manolis Website: http://web.mit.edu/manoli/ Manolis Twitter: https://twitter.com/manoliskellis Manolis Wikipedia: https://en.wikipedia.org/wiki/Manolis_Kellis PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ Full episodes playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOdP_8GztsuKi9nrraNbKKp4 Clips playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOeciFP3CBCIEElOJeitOr41 OUTLINE: 0:00 - Introduction 6:20 - Epigenome 10:28 - Evolution 15:26 - Neanderthals 27:15 - Origin of life on Earth 43:44 - Life is a fight against physics 49:56 - Life as a set of transformations 51:35 - Time scales 1:00:31 - Transformations of ideas in human civilization 1:05:19 - Life is more than a rat race 1:13:18 - Life sucks sometimes and that's okay 1:30:16 - Getting older 1:36:21 - The best of MIT 1:49:01 - Poem 1: The Snow 2:01:52 - Love 2:06:16 - Poem 2: The Tide Waters CONNECT: - Subscribe to this YouTube channel - Twitter: https://twitter.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/LexFridmanPage - Instagram: https://www.instagram.com/lexfridman - Medium: https://medium.com/@lexfridman - Support on Patreon: https://www.patreon.com/lexfridman