“When [we] first started thinking about Castleman disease and whether we could solve it or not, … we first said, well, surely “they” must be working on this?” But there was no “they”. “Don't assume that they's out there in a little factory tinkering…You can be they. So get up and go do it.” — Grant Mitchell on becoming problem solvers… Full episode: https://youtu.be/67_Z40Ap1pU?si=279bvv8uAPoa2wdl
Grant Mitchell is a seasoned entrepreneur, operator, and investor in the areas of health, technology, and machine learning. He is currently the co-founder and CEO of Every Cure, where he uses AI to research rare diseases and conduct drug repurposing. Grant joins the show to discuss the use of AI in rare drug research, the role of translational scientists, neglected knowledge, and MUCH MORE! Important Links: - Every Cure Website - https://everycure.org/about/ - Dr. Grant’s Twitter - https://twitter.com/grantwmitchell?lang=en - Dr. Grant’s LinkedIn - https://www.linkedin.com/in/grantwmitchell/ Show Notes: 0:00:00 Intro 0:01:01 Main podcast 0:06:20 The Organizational Problem in Pharma 0:15:41 Biomedical Knowledge Graphs 0:19:50 The Traditional Pharma Approach to Drug R&D 0:24:40 Risks in the World of AI-driven Drug Discovery 0:31:02 The Limits of AI for Medical Use 0:33:55 Biology’s Ignorome 0:43:33 The Role of Translators 0:47:43 The Typical Every Cure Supporter 0:53:14 Neglected Latent Knowledge 1:05:03 Grant as Emperor of the World Books/Essays Mentioned: - The AI Revolution - https://waitbutwhy.com/2015/01/artificial-intelligence-revolution-1.html; by Tim Urban (Wait But Why) - Ikigai - The Japanese Secret to a Long and Happy Life; by Héctor García & Francesc Miralles